Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.
Identifieur interne : 000987 ( Main/Exploration ); précédent : 000986; suivant : 000988Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans.
Auteurs : Olivier Perche [France] ; Juliette Vergnaud-Gauduchon [France] ; Christine Morand [France] ; Claude Dubray [France] ; Andrzej Mazur [France] ; Marie-Paule Vasson [France]Source :
- Clinical nutrition (Edinburgh, Scotland) [ 1532-1983 ] ; 2014.
English descriptors
- KwdEn :
- Antioxidants, B-Lymphocytes (drug effects), B-Lymphocytes (metabolism), Beverages, Citrus sinensis (chemistry), Cross-Over Studies, Healthy Volunteers, Hesperidin (pharmacology), Humans, Immunomodulation, Interleukin-2 (secretion), Interleukin-4 (secretion), Killer Cells, Natural (immunology), Male, Middle Aged, Monocytes (drug effects), Monocytes (metabolism), Neutrophils (drug effects), Neutrophils (metabolism), Polyphenols (pharmacology), Reactive Oxygen Species, T-Lymphocytes (drug effects), T-Lymphocytes (metabolism).
- MESH :
- chemical , pharmacology : Hesperidin, Polyphenols.
- chemical , secretion : Interleukin-2, Interleukin-4.
- chemical : Antioxidants, Reactive Oxygen Species.
- chemistry : Citrus sinensis.
- drug effects : B-Lymphocytes, Monocytes, Neutrophils, T-Lymphocytes.
- immunology : Killer Cells, Natural.
- metabolism : B-Lymphocytes, Monocytes, Neutrophils, T-Lymphocytes.
- Beverages, Cross-Over Studies, Healthy Volunteers, Humans, Immunomodulation, Male, Middle Aged.
Abstract
Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Reactive Oxygen Species (ROS) burst by polymorphonuclear neutrophil cells (PMN).
DOI: 10.1016/j.clnu.2013.03.012
PubMed: 23602614
Affiliations:
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Le document en format XML
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Médecine, F-63001 Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Clermont-Ferrand, Centre de Pharmacologie Clinique, Inserm, CIC 501, Univ Clermont 1, Faculté de Médecine, F-63001 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de recherche INRA, UMR 1019 INRA Université d'Auvergne, Unité de Nutrition Humaine, Clermont-Ferrand Theix</wicri:regionArea><wicri:noRegion>Clermont-Ferrand Theix</wicri:noRegion><wicri:noRegion>Clermont-Ferrand Theix</wicri:noRegion></affiliation></author><author><name sortKey="Vasson, Marie Paule" sort="Vasson, Marie Paule" uniqKey="Vasson M" first="Marie-Paule" last="Vasson">Marie-Paule Vasson</name><affiliation wicri:level="3"><nlm:affiliation>Centre anticancéreux Jean-Perrin, CHU, Unité de Nutrition, CLARA, F-63000 Clermont-Ferrand, France. Electronic address: m-paule.vasson@udamail.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre anticancéreux Jean-Perrin, CHU, Unité de Nutrition, CLARA, F-63000 Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical nutrition (Edinburgh, Scotland)</title><idno type="eISSN">1532-1983</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants</term><term>B-Lymphocytes (drug effects)</term><term>B-Lymphocytes (metabolism)</term><term>Beverages</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Healthy Volunteers</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Immunomodulation</term><term>Interleukin-2 (secretion)</term><term>Interleukin-4 (secretion)</term><term>Killer Cells, Natural (immunology)</term><term>Male</term><term>Middle Aged</term><term>Monocytes (drug effects)</term><term>Monocytes (metabolism)</term><term>Neutrophils (drug effects)</term><term>Neutrophils (metabolism)</term><term>Polyphenols (pharmacology)</term><term>Reactive Oxygen Species</term><term>T-Lymphocytes (drug effects)</term><term>T-Lymphocytes (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hesperidin</term><term>Polyphenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Interleukin-2</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antioxidants</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>B-Lymphocytes</term><term>Monocytes</term><term>Neutrophils</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term><term>Monocytes</term><term>Neutrophils</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Beverages</term><term>Cross-Over Studies</term><term>Healthy Volunteers</term><term>Humans</term><term>Immunomodulation</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Polyphenols exert a variety of biological properties, including antioxidant, immunomodulatory and antigenotoxic effects. In a randomized crossover study in healthy men, we investigated the effects of orange juice and its major polyphenolic compound hesperidin on a panel of immune cell functions, including cytokine secretion by leukocytes, lytic activity of NK cells, and the Reactive Oxygen Species (ROS) burst by polymorphonuclear neutrophil cells (PMN).</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Clermont-Ferrand</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Perche, Olivier" sort="Perche, Olivier" uniqKey="Perche O" first="Olivier" last="Perche">Olivier Perche</name></region><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><name sortKey="Vasson, Marie Paule" sort="Vasson, Marie Paule" uniqKey="Vasson M" first="Marie-Paule" last="Vasson">Marie-Paule Vasson</name><name sortKey="Vergnaud Gauduchon, Juliette" sort="Vergnaud Gauduchon, Juliette" uniqKey="Vergnaud Gauduchon J" first="Juliette" last="Vergnaud-Gauduchon">Juliette Vergnaud-Gauduchon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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